Andrew R. Buller

Assistant Professor (also Department of Chemistry)

Picture of Andrew R. BullerChemistry Shain Research Tower
Room 5112
1101 University Ave
Madison, WI 53706
Phone: (608) 265-8431
Overview · Publications · Lab Website


B.A./B.S., Biochemistry/Mathematics, University of Iowa
Ph.D., Biophysics, The Johns Hopkins University
Postdoctoral, Bioengineering, The California Institute of Technology

Areas of Study

Biomolecular Folding & Interactions
Chemical Biology
Quantitative Biology
Structural Biology
Systems & Synthetic Biology

Research Overview

The central theme of research in the Buller lab is understanding of how to engineer new biocatalytic reactions. We believe this is the ultimate test in our understanding of enzymology. Moreover, enzymes offer a green, sustainable route to performing difficult synthetic transformations. To do this, we combine the raw power of protein directed evolution with insights gleaned from decades of detailed mechistic and bioinformatic studies. Our long-term goals are to use these new catalysts to offer unique shortcuts to synthetic routes, to probe biological systems, and to engineer pathways for the sustainable biosynthesis of natural product analogs with altered pharmacologic properties.

Buller research image