Jon Audhya

Associate Professor

Picture of Jon AudhyaHector F. DeLuca Biochemical Sciences Building
Room 5214A
440 Henry Mall
Madison WI 53706
Phone: (608) 262-3761
Email: audhya@wisc.edu
Overview · Publications · Lab Website

Education

B.S. 1997, Brown University, Providence, RI
Ph.D. 2002, University of California, San Diego (S. Emr)
Postdoctoral 2003-07, Ludwig Institute for Cancer Research (K. Oegema).

Areas of Study

Cell Structure & Signaling
Developmental Biology
Membrane Dynamics & Proteins

Research Overview

Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.

Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage:www.audhyalab.org.