Elizabeth R. Wright

Professor (also with Morgridge Institute for Research)

Picture of Elizabeth R. WrightHector F. DeLuca Biochemistry Laboratories
Room 471B
433 Babcock Drive Madison, WI 53706-1544
Phone: (608) 265-0666
Email: erwright2@wisc.edu
Overview · Publications · Lab Website

Education

B.S., Biology, Columbus State University
B.S., Chemistry, Columbus State University
Ph.D., Chemistry, Emory University
Postdoctoral, Structural Biology, California Institute of Technology

Areas of Study

Biomolecular Folding & Interactions
Cell Structure & Signaling
Immunology & Virology
Membrane Dynamics & Proteins
Structural Biology

Research Overview

Develops and uses cryo-electron microscopy methods and molecular biology approaches to explore the 3D structures of viruses, bacteria, and mammalian cells

The work in the Wright lab uses cryo-EM to investigate the structures of many types of cells. We also develop methods for advancing this technology. The goal is to use this information to aid in the development of novel antimicrobials, therapeutics, and vaccines.

cryo image


Direct visualization of endogenous tethers on HIV-1 attached to HeLa cells by cryo-ET. HeLa cells transfected with pNLenv1-delta-U were imaged by cryo-ET. Tomographic slice (7.37 nm) of HIV-1 virions attached to plasma membrane. Immature and mature virions, maturation intermediates, and HIV budding from the plasma membrane were observed. Elements shown include HIV-1 virions (purple), immature Gag polyprotein (pink), mature cores (blue), tethers (green), and the plasma membrane (orange). Image courtesy of Joshua D. Strauss and Elizabeth R. Wright.