Julie Mitchell

Professor of Biochemistry and Mathematics

Picture of Julie MitchellHector F. DeLuca Biochemistry Building
Room 2104D
420 Henry Mall
Madison, WI 53706-1544
Phone: (608) 432-5853
Email: mitchell@biochem.wisc.edu
Overview · Publications · Lab Website

Education

Ph.D., Mathematics, University of California-Berkeley
B.A., Mathematics, San Jose State University

Areas of Study

Biomolecular Folding & Interactions
Quantitative Biology
Structural Biology

Research Overview

Predictive models of molecular interactions and protein design


Molecular interactions provide the essential language of biochemistry. Gene regulation, signaling and other physiological communication processes are controlled by networks of such interactions. It is natural to examine interactions in terms of the individual behaviors, which are largely dictated by structural features and random fluctuation. Because kinetic rates can be altered by environmental conditions such as temperature, and the basis for this is largely structural, the system-wide behavior is intimately tied to structural detail. Our goal is to use predictive models to explore structural characterizations of protein association.  The use of computational tools based on physics and experimental data helps us uncover mechanisms of protein association, predict the effects of mutations, and explore protein design.