Ophelia Venturelli

Assistant Professor (also Bacteriology and Chemical and Biological Engineering)

Picture of Ophelia VenturelliHector F. DeLuca Biochemical Sciences Building
Room 3204C
440 Henry Mall
Madison, WI 53706-1544
Phone: (608) 263-7017
Email: venturelli@wisc.edu
Overview · Publications · Lab Website

Education

B.S. Stanford University, 2002-2006
PhD California Institute of Technology, 2007-2013
Postdoctoral Fellow, UC Berkeley, 2013-2016

Areas of Study

Cell Structure & Signaling
Chemical Biology
Gene Expression & RNA Biology
Quantitative Biology
Systems & Synthetic Biology

Research Overview

Understanding and engineering microbial communities across space and time

The Venturelli Lab aims to understand and engineer the spatiotemporal behaviors of microbial communities. We seek to elucidate the molecular and ecological design principles of microbial communities using tools from systems & synthetic biology. Our lab uses microfabrication methods to probe how spatial heterogeneity influences microbial communities and develops high-throughput methods to study microbial interactions in microbiomes. A major goal is to design novel strategies to precisely shift microbiomes to desired metabolic states.

We are fascinated by the complexity of the human gut microbiome and how to control microbiome functions. We study how microbial interaction networks impact the assembly, stability and functions of the human gut microbiome. In addition, we design novel circuits in key commensal or probiotic bacteria to sense and respond to environmental stimuli for therapeutic applications.

Schematic of a microbial interaction network

 

Schematic of a microbial interaction network
highlighting they key intracellular networks
and metabolites mediating each interaction.