Joshua J. Coon

Professor, Departments of Biomolecular Chemistry and Chemistry Lab Website 263-1718

4260B HF DeLuca Biochemical Sciences Building
440 Henry Mall
Madison WI 53706-1535

Starting Aug 7 the lab will be moving from Genetics Biotech Center to the Biochemical Sciences Building


B.S., Central Michigan University
Ph.D., University of Florida
Postdoctoral, University of Virginia

Bioanalytical chemistry, mass spectrometry and proteomics

The Coon lab develops and applies mass spectrometric technology to study human health. We use these tools to answer fundamental questions in cell biology and to study human diseases including Alzheimer’s, diabetes, heart failure, cancer, obesity, asthma, among several others.

The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including nucleic acids, proteins, and metabolites. High-throughput technologies for gene and transcript measurement are well-developed and broadly accessible, and, as such, have had a fantastic and transformative impact on modern biology and medicine. For numerous reasons, methods for global analysis of proteins and metabolites – crucial biological effector molecules – are less evolved and markedly less accessible. The overarching mission of my program is to (1) facilitate expedient, comprehensive analysis of proteins and metabolites by innovating new mass spectrometric technologies and (2) apply these techniques to advance biomedical research.

Image of Coon lab publications

Photo of Josh Coon

Areas of Expertise

  • Cell Structure & Signaling
  • Developmental Biology
  • Quantitative Biology
  • Systems & Synthetic Biology