Cryo-EM Facility Coming to Department to Serve Campus Researchers

Cryo-EM images of fruit fly cell mitochondria

Structural biology and collaboration are two strong points at the University of Wisconsin–Madison. In keeping with this tradition, a concerted cross-campus effort partly spearheaded by the Department of Biochemistry is working to bring a cryo-electron microscopy (cryo-EM) facility to campus.

Cryo-EM is a burgeoning tool that can help UW–Madison researchers make significant contributions to many areas of structural biology, including enzymology, virology, cell biology, and medicine. These discoveries can lead to a better understanding of many diseases and possible treatments.

“I think cryo-EM has emerged as an indispensable method for structural analysis in the biosciences,” says biochemistry professor Robert Landick, who is one of the leaders on the project. “It is not hyperbole to say that it is revolutionizing our understanding of large macromolecular machines. For UW–Madison to remain a powerhouse in bioscience research, it is crucial that modern cryo-EM capabilities be brought to campus.”

The facility will be housed in a 1,250-square-foot space in the Hector F. DeLuca Biochemistry Laboratories building but its users will be from across campus. Numerous colleges, research centers, departments, and researchers are coming together to secure the resources needed to establish the facility. Among those collaborating on projects and supporting the multi-million-dollar facility are the Morgridge Institute for Research, Materials Science Center, UW Carbone Cancer Center, Vice Chancellor for Research and Graduate Education, and School of Medicine and Public Health.

Read more about this upcoming facility at the link below.