Mass Spectrometry Fueling New Explorations at the Carbone Cancer Center

When biomolecular chemistry professor Josh Coon, also an investigator at the Morgridge Institute, first started developing scientific instruments to measure molecules in living systems, his criteria for finding partners on the UW–Madison campus were simple and clear. “We were technology people interested in making better measurements, and we needed cool projects to help us push …

IPiB Thesis Defense Dec. 12: Josh Mitchell

Eosinophils (EOS) have broad immunomodulatory and inflammatory effects — these white blood cells are implicated in eosinophilic asthma, eradicating parasitic infections, involvement in the gut microbiome and tumor microenvironment, and more — yet scientists still don’t have a complete understanding of how they are activated, or how they release granular content and deliver their noxious …

IPiB Thesis Defense Dec. 8: Edrees Rashan

Edrees (Eddie) Rashan became interested in the life sciences as a college sophomore. He’d heard of DNA but never really appreciated what it looked like, how it was made, or the characteristics that make it so important to life. He eventually switched majors from engineering to biochemistry to learn about biomolecules and how they function …

IPiB Thesis Defense Dec. 2: Sophie Lewandowski

Insulin is secreted by the pancreas in response to elevated blood glucose levels. Insufficient amounts of insulin can result in Type II diabetes, while excess can lead to hypoglycemia — both life-threatening conditions. Sophie Lewandowski, an IPiB graduate student in the Merrins Lab, studies how pyruvate kinase fits into insulin secretion and regulation. Pyruvate kinase, …

IPiB Thesis Defense Nov. 11: Peyton Spreacker

Antibiotic resistance is one of the great public health problems of our time. Since Peyton Spreacker joined IPiB as a member of the Henzler-Wildman Lab, she has been studying the role multidrug efflux proteins play in this phenomenon. “We know that these proteins can take drugs out of bacterial cells, making them less effective,” says …

IPiB Thesis Defense Nov. 4: Miguel Angel Osorio Garcia

Cell survival hinges on a host of processes, one of which is DNA repair. Though research has shown that the RadD protein plays an important role in processing damaged or branched DNA in E. coli, previous efforts to demonstrate DNA unwinding activity for RadD have failed. Miguel Angel Osorio Garcia, an IPiB graduate student in …

IPiB Graduate Student Named Recipient of First CALS B.R. DasGupta Graduate Award

Nithesh Chandrasekharan has been named one of the first recipients of the B.R. DasGupta Graduate Award. The award provides $5,000 to an international graduate student enrolled in the College of Agricultural and Life Sciences in bacteriology, biochemistry, food science, or microbiology. Dr. Vijoya (Joya) DasGupta established the award in memory of her late husband Bibhuti …