Cell Structure & Signaling

Stefely, Jonathan

Comparative metabolism – from pathogenic amoeba to humans – to uncover both new biology and new drug targets

Deorphanizing biochemical pathways that regulate nutrient metabolism in mammals

Stem cells, brain development and regeneration, membrane and cytoskeleton dynamics, Danionella fish and Drosophila, super-resolution microscopy

Interactions of the gut microbiome with the host; intestinal metabolism in health and disease

Function and regulation of RNA condensates in development

Molecular mechanisms of pain signaling

Identification of adipocyte functional pathways using chemoproteomics methods

Studying the structure and dynamics of biological macromolecules using cryo-EM

Cellular stress responses, organelle dysfunction and interaction, beta cell function and survival, diabetes

Molecular biology of eukaryotic DNA viruses, gene expression regulation, apoptosis, retrotransposons