Chemical Biology & Enzymology

Denu, John M.

Mechanisms of chromatin dynamics, epigenetic, metabolism and signaling

Biochemical, catalytic, and spectroscopic studies of redox active enzymes; protein engineering

Proteins and protein-like molecules: design, synthesis, structure and function

Dynamics and function of integral membrane proteins, secondary active transport, ion channels

Mechanistic studies of eukaryotic RNA processing using chemical, genetic, and biophysical approaches

Structural mechanisms of genome maintenance

Understanding and designing biomolecular systems using high-throughput functional assays

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics

Biochemical and computational studies of membrane protein interactions