Chemical Biology & Enzymology

Stefely, Jonathan

Comparative metabolism – from pathogenic amoeba to humans – to uncover both new biology and new drug targets

Deorphanizing biochemical pathways that regulate nutrient metabolism in mammals

Predicting biomolecular dynamics; understanding roles of dynamics in function, evolution, design

Discovery, characterization, and evolution of enzymes for biocatalysis and chemical biology

Protein engineering, directed evolution, and protein folding

Interactions of the gut microbiome with the host; intestinal metabolism in health and disease

Function and regulation of RNA condensates in development

Identification of adipocyte functional pathways using chemoproteomics methods

Human telomere replication and maintenance

Protein structure, folding, dynamics and aggregation in the cell; role of ribosome and molecular chaperones