Quantitative Biology

Harrison, Melissa M.

Transcriptional regulation during development

Dynamics and function of integral membrane proteins, secondary active transport, ion channels

Mechanistic studies of eukaryotic RNA processing using chemical, genetic, and biophysical approaches

Structural mechanisms of genome maintenance

Structural and biochemical exploration of RNA virus entry and replication

RNA polymerase structure/function; regulation of transcript elongation in bacteria and humans

Mechanisms of chromatin assembly, gene silencing, and epigenetic inheritance

Understanding and designing biomolecular systems using high-throughput functional assays

Signal transduction in eukaryotes, genomic technologies, membrane receptors and ion transporters

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics