Systems & Synthetic Biology

Stefely, Jonathan

Comparative metabolism – from pathogenic amoeba to humans – to uncover both new biology and new drug targets

Discovery, characterization, and evolution of enzymes for biocatalysis and chemical biology

Protein engineering, directed evolution, and protein folding

Dynamical metabolic regulation, immunometabolism, metabolic underpinnings of cell function

Protein structure, folding, dynamics and aggregation in the cell; role of ribosome and molecular chaperones

RNA polymerase structure/function; regulation of transcript elongation in bacteria and humans

Understanding and designing biomolecular systems using high-throughput functional assays

Signal transduction in eukaryotes, genomic technologies, membrane receptors and ion transporters

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics

Mathematical and computational methods in biology